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However, the inflammatory response surrounding the herniation, the condition of the annulus fibrosus, and the health of supporting musculature all represent potential targets
Dipeptidyl peptidase-4 inhibitors (DPP4i) and Glucagon Like Peptide-1 Receptor Agonists (GLP1-RA) were introduced around 2006 and are now increasingly prescribed due to their demonstrated safety in advanced kidney disease 10,11,12
introduce them gradually and according to individual tolerance
However, acetazolamide is poorly tolerated in patients while GLP-1RAs are typically better tolerated, with only transient nausea as the predominant adverse effect [105]
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